According to Klein, the purpose of the work is to understand how the immune response to coronavirus SARS-CoV-2, and to identify potent antibodies that could be used for the prevention and treatment of coronavirus disease.
A team of scientists from Marburg, Frankfurt, Munich, Tubingen and Israel searched for antibodies to SARS-CoV-2 in 12 people who managed to defeat the coronavirus infection. They studied over four thousand SARS-CoV-2 – specific B cells – at the level of individual molecules and were able to partially decode the immune response (by producing Ig immunoglobulins to a foreign antigen) to coronavirus.
Researchers reconstructed 255 antibodies, which were then tested in the laboratory of Professor Stefan Becker in Marburg for their ability to neutralize SARS-CoV-2. 28 of them reached the final.
It was hoped that the vaccine would help provide quick protection against infection. In addition to preventing infection and directly treating patients with Covid-19, antibodies can be used for prophylaxis after exposure to an infected person.